Surapon TangvarasittichaiNimit SriprangTalabporn HarnroongrojSupranee ChangbumrungMahidol UniversityNaresuan University2018-06-212018-06-212005-11-01Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.6 (2005), 1543-1551012515622-s2.0-33645025935https://repository.li.mahidol.ac.th/handle/20.500.14594/16749The antimutagenic activity of Sesbania javanica Miq. or Sano, an edible vegetable flower DMSO extract against aflatoxin B1 (AFB1) benzo (a) pyrene [B(a)P], was evaluated by means of the Ames' test. The Sesbania javanica Miq. flower DMSO extract showed a strong inhibitory effect against AFB 1 and B(a)P mutagens. A search to isolate the major flavonoid in Sesbania javanica Miq. flower extract found the flavonol glycoside, Quercetin 3-2G-rhamnosylrutinoside, which was confirmed by its physicochemical properties as a major constituent of the flower. Quercetin 3-2 G-rhamnosylrutinoside (207 pg/plate) also showed a strong inhibitory effect against AFB1 and B(a)P with a more than 70% inhibition rate.Mahidol UniversityMedicineArticleSCOPUS