P. NuntnarumitP. ThanomsinghA. LimrungsikulS. WanitkunT. SirisopikunP. AusayapaoFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityMaharaj Nakhon Ratchasima Hospital2019-08-282019-08-282018-02-01Journal of Perinatology. Vol.38, No.2 (2018), 181-18414765543074383462-s2.0-85041356988https://repository.li.mahidol.ac.th/handle/20.500.14594/46969© 2018 Nature America, Inc., part of Springer Nature. All rights reserved. Objective:To evaluate the predictive abilities of pulse oximetry screening (POS) for critical congenital heart disease (CRIT.CHD) at two different hospital settings in Thailand.Study Design:The study was conducted in healthy newborns at Ramathibodi Hospital (RH), a university hospital and Maharat Nakhon Ratchasima Hospital (MH), a regional hospital. Positive POS was defined as oxygen saturation (SpO2) <95% or difference between pre- and postductal SpO2 >3%.Results:Of 11 407 live births, 10 603 (92.9%) newborns were enrolled with a follow-up rate at 1 month of 78.3%. Incidence of CRIT.CHD (per 1000 live births) at RH and MH were 5.7 and 2.7, respectively. POS could detect three newborns who would have had a missed diagnosis. Sensitivity of POS for CRIT.CHD at RH was 82.3% vs 100% at MH. Overall specificity was 99.9% and false-positive rate was 0.009%. Combination of POS and physical examination (PE) enhanced detection ability to 100% at both hospitals.Conclusion:POS combined with PE improved detection of CRIT.CHD. Routine POS is useful in personnel-limited settings.Mahidol UniversityMedicineArticleSCOPUS10.1038/jp.2017.168