Ahmad M. MansourRobert E. FosterRoberto Gallego-PinazoMarilita M. MoschosRobert A. SiskJay ChhablaniDuangnate RojanapornTharikarn SujirakulJ. Fernando ArevaloLuiz H. LimaLihteh WuAbdulrazzak CharbajiAli O. SaatciHana A. MansourClara Martinez-RubioYogin PatelSankeert GangakhedkarRafik Hariri University HospitalUniversité LibanaiseLebanese American UniversityAmerican University of BeirutHospital Universitari i Politècnic La FeJohns Hopkins Bayview Medical CenterNational and Kapodistrian University of AthensUniversity of CincinnatiL.V. Prasad Eye Institute IndiaWilmer Eye InstituteFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityUniversidade Federal de Sao PauloDokuz Eylül ÜniversitesiRutnin Eye HospitalCoffee Research Institute of Costa Rica2020-01-272020-01-272019-06-01Retina. Vol.39, No.6 (2019), 1133-1141153928640275004X2-s2.0-85066424799https://repository.li.mahidol.ac.th/handle/20.500.14594/51634© 2019 Ophthalmic Communications Society, Inc. Purpose:There is no established therapy for exudative-hemorrhagic complications in primary retinal arteriolar macroaneurysm (RAM).Methods:Retrospective multicenter interventional study of anti-vascular endothelial growth factor in symptomatic RAMs. Central macular thickness in m and best-corrected visual acuity in logMar were correlated with the RAM size and distance to the macula. Statistical analyses were performed using paired comparisons and Pearson correlation.Results:Thirty-two eyes (32 patients) were treated with a mean of 2.7 injections over a mean follow-up of 16.6 months. Initial best-corrected visual acuity correlated with the RAM size and distance to the macula (P = 0.02). Central macular thickness decreased by 131,180, and 211 m at 1, 2, and 3 months after the first injection (P < 0.001). Best-corrected visual acuity improved by 0.47 and 0.38 Early Treatment Diabetic Retinopathy Study lines at 2 and 3 months (P = 0.005). Anti-vascular endothelial growth factor response correlated with the RAM size (P = 0.04) and the distance to the macula (P = 0.009).Conclusion:Symptomatic RAMs can be treated successfully with anti-vascular endothelial growth factor injections, leading to a decrease in macular edema.Mahidol UniversityMedicineArticleSCOPUS10.1097/IAE.0000000000002131