Ratchanok PingaewApilak WorachartcheewanVeda PrachayasittikulSupaluk PrachayasittikulSomsak RuchirawatVirapong PrachayasittikulSrinakharinwirot UniversityMahidol UniversityChulabhorn Research Institute2018-10-192018-10-192013-11-01Letters in Drug Design and Discovery. Vol.10, No.9 (2013), 859-8641875628X157018082-s2.0-84887864374https://repository.li.mahidol.ac.th/handle/20.500.14594/31175Metal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been investigated for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of 8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results demonstrate an application of 8AQ molecule as a potential ligand for new bioactive compounds. ©2013 Bentham Science Publishers.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.2174/15701808113109990004