Vipa TangkrisanavinontChumpol PholpramoolMahidol University2018-06-012018-06-011979-11-01Pflügers Archiv European Journal of Physiology. Vol.382, No.3 (1979), 275-27714322013003167682-s2.0-0018688781https://repository.li.mahidol.ac.th/handle/20.500.14594/13149A possible role of extracellular free Ca 2+ in methacholine-induced fluid secretion in the in vivo rabbit lacrimal gland has been investigated. Lowering the extracellular Ca 2+ concentration by either intra-arterial injection or infusion of EGTA at doses which caused no systemic effects produced a dose related and reversible inhibition of methacholine-induced secretion. The inhibitory effect of EGTA was diminished when EGTA chelated with CaCl 2 in varying concentration ratios was administered. On the other hand, intra-arterial injection of CaCl 2 potentiated fluid secretion stimulated by submaximal doses of methacholine. These results suggest that fluid secretion from the rabbit lacrimal gland is dependent on the extracellular free Ca 2+ concentration. © 1979 Springer-Verlag.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1007/BF00583713