Thant M.T.Khine H.E.E.Nealiga J.Q.L.Chatsumpun N.Chaotham C.Sritularak B.Likhitwitayawuid K.Mahidol University2023-06-182023-06-182022-02-01Molecules Vol.27 No.4 (2022)https://repository.li.mahidol.ac.th/handle/20.500.14594/83835Chemical investigation of Dendrobium delacourii revealed 11 phenolic compounds, and the structures of these compounds were determined by analysis of their NMR and HR-ESI-MS data. All compounds were investigated for their α-glucosidase inhibitory activity and anti-adipogenic properties. Phoyunnanin E (10) and phoyunnanin C (11) showed the most potent α-glucosidase inhibition by comparing with acarbose, which was used as a positive control. Kinetic study revealed the non-competitive inhibitors against the enzyme. For anti-adipogenic activity, densifloral B (3) showed the strongest inhibition when compared with oxyresveratrol (positive control). In addition, densifloral B might be responsible for the inhibition of adipocyte differentiation via downregulating the expression of peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer-binding protein alpha (C/EBPα), which are major transcription factors in adipogenesis.Biochemistry, Genetics and Molecular BiologyArticleSCOPUS10.3390/molecules270411562-s2.0-851245980101420304935208957