Jisnuson SvastiChantragan SrisomsapPrance WinichagoonSuthat FucharoenChulabhorn Research InstituteMahidol UniversityThe Institute of Science and Technology for Research and Development, Mahidol University2018-09-072018-09-071999-12-01Southeast Asian Journal of Tropical Medicine and Public Health. Vol.30, No.SUPPL. 2 (1999), 88-93012515622-s2.0-0033301445https://repository.li.mahidol.ac.th/handle/20.500.14594/25555In Thailand, some 20 different abnormal hemoglobins have been found in the last 30 years. Most are rare except tor Hb E and Hb Constant Spring, found with frequencies of 10-53% and 1-8% respectively in different parts of the country. Most mutations are point mutations, but C-terminal elongations and crossing-over arc also found. Most mutations do not cause clinical problems, but some can give rise to mild thalassemia syndromes, or cause problems in association with thalassemia. Abnormal hemoglobins may often be diagnosed by electrophoresis, but some variants have the same mobility, so that other techniques are required, such as HPLC and the use of allele-specific polymerase reaction or oligonucleotide probes . Novel variants, not previously described in Thailand, require structural analysis at the protein and DNA level.Mahidol UniversityMedicineArticleSCOPUS