Tanakorn KittikoolKunita PhakdeeyothinTeera ChantarojsiriSirilata YotphanMahidol University2022-08-042022-08-042021-06-07European Journal of Organic Chemistry. Vol.2021, No.21 (2021), 3071-3078109906901434193X2-s2.0-85110470805https://repository.li.mahidol.ac.th/handle/20.500.14594/76605A highly efficient and regioselective manganese-induced radical oxidative direct C−P bond formation between 2-pyridones and secondary phosphine oxides was developed. The C3-selective phosphinoylation was conveniently achieved through a combination of substoichiometric manganese and persulfate oxidant under mild conditions. Various 3-phosphinoylated pyridone products can be obtained in moderate to high yields. Preliminary mechanistic studies suggest that the reaction is likely to involve a radical pathway induced by catalytically active Mn3+ species.Mahidol UniversityChemistryArticleSCOPUS10.1002/ejoc.202100336