Praewpan KatrunChutima KuhakarnKhon Kaen UniversityMahidol University2020-01-272020-01-272019-04-04Tetrahedron Letters. Vol.60, No.14 (2019), 989-99318733581004040392-s2.0-85062459762https://repository.li.mahidol.ac.th/handle/20.500.14594/50205© 2019 Elsevier Ltd A convenient halogenation of 2-arylimidazo[1,2-a]pyridines using sodium chloride/bromide/iodide as the halogen sources in the presence of K 2 S 2 O 8 as an easy-to-handle oxidizing agent was developed. The present work offers an efficient and rapid access to 3-chloro-, 3-bromo- and 3-iodo-2-arylimidazo[1,2-a]pyridines which can be readily converted to C3-substituted imidazo[1,2-a]pyridines by cross-coupling reactions.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1016/j.tetlet.2019.03.008