Jaray JaratjaroonphongSupaporn SathalalaiPrapapan TechasauvapakVichai ReutrakulFaculty of ScienceMahidol University2018-09-132018-09-132009-11-04Tetrahedron Letters. Vol.50, No.44 (2009), 6012-6015004040392-s2.0-70149089461https://repository.li.mahidol.ac.th/handle/20.500.14594/27119Iodine is shown to be an efficient catalyst for the Friedel-Crafts alkylation of arenes with a wide variety of aldehydes in toluene under 'open-flask' and mild conditions. In the presence of 10 mol % of iodine, the reaction of arenes with aromatic aldehydes gives the corresponding triarylmethane derivatives (TRAMs), regioselectively, in good to excellent yields. On the other hand, a series of diarylalkane derivatives is synthesized smoothly by the reaction with aliphatic aldehydes. © 2009 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.tetlet.2009.08.036