Kamolchanok TianpanichSurasak PrachyaSuthep WiyakruttaChulabhorn MahidolSomsak RuchirawatPrasat KittakoopCenter for Environmental HealthChulabhorn Research InstituteMahidol University2018-05-032018-05-032011-01-28Journal of Natural Products. Vol.74, No.1 (2011), 79-8115206025016338642-s2.0-79951548291https://repository.li.mahidol.ac.th/handle/20.500.14594/11602Five known isocoumarins, monocerin (1), derivative 2, and fusarentin derivatives 3-5, and a new phthalide (6) were isolated from the endophytic fungus Colletotrichum sp. 2 selectively exhibited cytotoxic activity toward the HepG2 cell line. Compounds 2 and 4 scavenged 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals (IC50 values of 23.4 and 16.4 μM, respectively) and inhibited superoxide anion radical formation (IC50 values of 52.6 and 4.3 μM, respectively). The C-7 hydroxyl group in 2 and 4 might be important for radical scavenging activities. Isocoumarins 1-3 and phthalide 6 showed p otent antioxidant activity. © 2011 American Chemical Society and American Society of Pharmacognosy.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np1003752