J. PauschA. HolstegeT. AnukarahanontaD. KepplerW. GerokUniversitat Freiburg im BreisgauMahidol University2018-10-122018-10-121985-01-01Advances in Enzyme Regulation. Vol.24, No.C (1985), 429-434006525712-s2.0-0022193658https://repository.li.mahidol.ac.th/handle/123456789/30755Sixteen unselected patients with non-resectable hepatocellular carcinoma were treated in a phase I study with 261 cycles of d-galactosamine and 6-azauridine prior to 5-fluorouridine. Thirty % of the patients survived for more than one year without signs of tumor progression and with an unchanged performance status. The compatibility of this chemotherapeutical method was quite satisafactory. The only extrahepatic side effect was a leucopenia and/or thrombocytopenia which was reversible upon reduction of the 5-fluoroudine dose. The heterogeneity of the 16 patients treated to date does not allow a definite statistical evaluation of the reported clinical observations and results. A final decision about the clinical applicability of this concept of a selective chemotherapy of hepatocellular carcinomal requires further experience. © 1985.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1016/0065-2571(85)90091-3