Facile oxidative hydrolysis of acetals to esters using hypervalent iodine(III)/LiBr combination in water

Waraporn PanchanSupanimit ChiampanichayakulDeanna L. SnyderSiriporn YodbuntungManat PohmakotrVichai ReutrakulThaworn JaipetchChutima KuhakarnMahidol University2018-09-242018-09-242010-04-03Tetrahedron. Vol.66, No.14 (2010), 2732-2735004040202-s2.0-77649182466https://repository.li.mahidol.ac.th/handle/123456789/28738The combination of (diacetoxy)iodobenzene (PhI(OAc)2, DIB) and lithium bromide (LiBr) efficiently oxidized cyclic and acyclic acetals to the corresponding hydroxyalkyl carboxylic esters and simple esters in good to excellent yields. The merits of this reaction are that it employs commercially available and non-explosive hypervalent iodine(III) reagent, water as the solvent, a short reaction time, and mild reaction conditions. © 2010 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsFacile oxidative hydrolysis of acetals to esters using hypervalent iodine(III)/LiBr combination in waterArticleSCOPUS10.1016/j.tet.2010.01.098