Chanaki AmaratungaBenoit WitkowskiDalin DekVorleak TryNimol KhimOlivo MiottoDidier MénardRick M. FairhurstNational Institute of Allergy and Infectious DiseasesInstitut Pasteur du CambodgeNational Center for Parasitology, Entomology and Malaria ControlUniversity of OxfordMahidol UniversityWellcome Trust Sanger Institute2018-11-092018-11-092014-01-01Antimicrobial Agents and Chemotherapy. Vol.58, No.8 (2014), 4935-493710986596006648042-s2.0-84905373498https://repository.li.mahidol.ac.th/handle/123456789/34808Reduced Plasmodium falciparum sensitivity to short-course artemisinin (ART) monotherapy manifests as a long parasite clearance half-life. We recently defined three parasite founder populations with long half-lives in Pursat, western Cambodia, where reduced ART sensitivity is prevalent. Using the ring-stage survival assay, we show that these founder populations have reduced ART sensitivity in vitro at the early ring stage of parasite development and that a genetically admixed population contains subsets of parasites with normal or reduced ART sensitivity. Copyright © 2014, American Society for Microbiology. All Rights Reserved.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1128/AAC.03055-14