Chang A.Pausawasdi N.Charatcharoenwitthaya P.Kaosombatwattana U.Sriprayoon T.Limsrivilai J.Prachayakul V.Leelakusolvong S.Mahidol University2023-06-182023-06-182022-08-01Digestive Diseases and Sciences Vol.67 No.8 (2022) , 4122-413001632116https://repository.li.mahidol.ac.th/handle/20.500.14594/83667Background: Aggressive intravenous fluid hydration, by administering 3500 mL of lactated Ringer’s solution (LRS) in 9 h with a peri-procedural bolus, reduces post-ERCP pancreatitis (PEP) incidence. A concern of this strategy is adverse events related to volume overload; however, the impact of fluid hydration over an extended period without a bolus on PEP is unknown. Aim: To assess the effect of continuous infusion of high-volume fluid at a constant rate over 24 h on PEP incidence and severity. Methods: Two-hundred patients were randomly assigned (1:1) to receive either 3600 mL of LRS in 24 h starting 2 h before the ERCP (high-volume group) or maintenance fluid hydration calculated by the Holliday-Segar method (control group). Results: The mean age of the patients was 50.6 ± 11.6 years. The predominant indications were choledocholithiasis (48%) and malignancies (32%). Patient demographics and PEP risk factors were similar in both groups. Patients in the high-volume group received significantly more fluid than the control group (3600 vs. 2413 ml, P < 0.001). PEP incidence was not different between the high-volume and the control group (14% vs. 15%; relative risk 0.93: 95% CI 0.48–1.83, P = 0.84). There were no differences in moderate to severe PEP (3% vs. 4%; relative risk 0.75: 95% CI, 0.17–3.27, P = 1.00). Subgroup analysis did not show a benefit in high-risk patients. Only one patient in the control group developed peripheral edema. Conclusions: An infusion of high-volume hydration over 24 h is not sufficient to provide optimal hydration for PEP prevention. Clinical Trial Registry Number: No. NCT 02821546.Biochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1007/s10620-021-07256-z2-s2.0-851171266591573256834655014