S. PrasartkaewA. BunyaratvejS. FucharoenP. WasiFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityMahidol University2018-02-272018-02-271986-01-01Journal of Clinical Pathology. Vol.39, No.12 (1986), 1299-1303002197462-s2.0-0022889356https://repository.li.mahidol.ac.th/handle/20.500.14594/9837The activities of erythrocyte antioxidative enzymes were measured in two groups of patients with different genotypes of haemoglobin (Hb) H disease: 21 with α-thalassaemia or α-thalassaemia 2 (α-thalassaemia 1/2) and 21 with α-thalassaemia l/Hb Constant Spring (HbCS). They were compared with 21 normal subjects. Both genotypes of Hb H disease had increased activities of erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase when compared with those of controls. Comparison of the two genotypes showed that subjects with α-thalassaemia /Hb CS, the more severe disease, had higher SOD and GSH-Px activities but lower catalase activity than those with α-thalassaemia 1/2. This indicates that there are compensatory mechanisms in Hb H erythrocytes to cope with increased generation of oxygen free radicals as a result of increased excess ,β chain.Mahidol UniversityMedicineArticleSCOPUS10.1136/jcp.39.12.1299