Norbert GattermannCarlo FinelliMatteo Della PortaPierre FenauxArnold GanserAgnes Guerci-BreslerMathias SchmidKerry TaylorDominique VassilieffDany HabrGabor DomokosBernard RoubertChristian RoseL. AgaogluG. AlimenaD. AlonsoS. AmeE. AngelucciB. ArrizabalagaM. Athanasiou-MetaxaB. AugustsonY. AydinokA. BabaM. BaccaraniJ. BeckP. BerisO. Beyne-RauzyH. BirgensD. BordessouleC. Borgna-PignattiA. BoslyK. BouabdallahD. BowdenD. BowenD. BronM. D. CappelliniM. CapraG. CartronM. CazzolaC. ChalkiasL. L. ChanS. ChancharuneeC. ChapmanP. CharoenkwanE. ChasapopoulouS. ChezeA. ChuansumritP. CianciulliC. DauriacM. DelforgeG. DölkenH. DombretJ. DuysterT. EconomopoulosG. EhningerM. ElalfyA. El-BeshlawyL. EnggaardG. FilletA. FilosaG. ForniR. GalanelloG. GastlS. GiraudierA. GoldfarbA. GriggF. GumrukS. Y. HaD. HaaseB. HeinrichM. HertzbergJ. HoH. C. HsuS. HuangM. Hunault-BergerB. InusaD. JaulmesJ. JensenA. KattamisY. KilincK. H. KimS. KinseyL. KjeldsenA. KorenM. E. LaiY. LaiJ. W. LeeK. H. LeeS. H. LeeL. LegrosC. LiC. K. LiQ. LiK. H. LinW. LinkeschM. LübbertD. LutzA. J. Mohamed ThalhaG. MuftiP. MuusHeinrich Heine UniversitatAlma Mater Studiorum Universita di BolognaUniversita degli Studi di PaviaHopital AvicenneMedizinische Hochschule Hannover (MHH)Hopital Brabois AdultesUniversitatsklinikum UlmMater HospitalUniversite Paris DescartesNovartis PharmaceuticalsNovartis International AGHopital Saint Vincent-de-Paul GHICLIstanbul UniversitesiAzienda Policlinico Umberto IHospital Universitario Virgen del RocioHopital de HautepierreAzienda Ospedaliera Brotzu - BusincoHospital de CruzesAristotle University of ThessalonikiSir Charles Gairdner HospitalEge UniversitesiHospital Universiti Sains MalaysiaOsp. BolognaKlinikum der Johannes-Gutenberg-Universitat und Fachbereich MedizinHopitaux universitaires de GeneveHopital PurpanAmtssygehusetl HerlevCHU de LimogesAz. 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Ö. Krankenhausder ElisabethinenHospital Universiti Kebangsaan MalaysiaKing's College Hospital NHS Foundation TrustRadboud University Nijmegen Medical Centre2018-09-242018-09-242010-09-01Leukemia Research. Vol.34, No.9 (2010), 1143-1150014521262-s2.0-77955268192https://repository.li.mahidol.ac.th/handle/20.500.14594/28652The prospective 1-year EPIC study enrolled 341 patients with myelodysplastic syndromes (MDS); although baseline iron burden was >2500. ng/mL, ∼50% were chelation-naïve. Overall median serum ferritin decreased significantly at 1 year (p=0.002). Decreases occurred irrespective of whether patients were chelation-naïve or previously chelated; changes were dependent on dose adjustments and ongoing iron intake. Sustained reductions in labile plasma iron were observed. Discontinuation rate (48.7%) and adverse event profile were consistent with previously reported deferasirox data in MDS. Alanine aminotransferase levels decreased significantly; change correlated significantly with reduction in serum ferritin (p<0.0001). This large dataset prospectively confirms the efficacy and well characterizes the safety profile of deferasirox in MDS. © 2010 Elsevier Ltd.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1016/j.leukres.2010.03.009