Songsak RoekringDuncan R. SmithMahidol University2018-09-242018-09-242010-07-01Journal of Invertebrate Pathology. Vol.104, No.3 (2010), 239-24110960805002220112-s2.0-77954862362https://repository.li.mahidol.ac.th/handle/20.500.14594/28485The mechanism of death in densovirus infected mosquitoes remains unexplored. This study investigated the cellular consequences of densovirus infection in Aedes aegypti mosquitoes after a second generation challenge with a densovirus isolated from adult Aedes albopictus mosquitoes in Thailand (AThDNV). Specimens were analyzed by TUNEL assay, fluorescent in situ hybridization (FISH) and a calorimic assay to detect activation of caspase 3-like activity. After challenge, moribund mosquitoes showed considerable evidence of TUNEL positive cells. The caspase 3-like activity assay showed that the presence of TUNEL positive cells was associated with increased levels of activated caspase 3-like activity in AThDNV infected mosquitoes. © 2010 Elsevier Inc.Mahidol UniversityAgricultural and Biological SciencesMedicineArticleSCOPUS10.1016/j.jip.2010.04.002