D. WallerS. KrishnaN. J. WhiteA. JammehD. KwiatkowskiN. J. WhiteJ. KarbwangP. MoluntoNuffield Department of Clinical MedicineHammersmith HospitalRoyal Victoria Teaching Hospital GambiaMedical Research Council Laboratories GambiaMahidol University2018-06-142018-06-141990-01-01Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.84, No.4 (1990), 488-49118783503003592032-s2.0-0025118490https://repository.li.mahidol.ac.th/handle/20.500.14594/15974Plasma quinine concentrations were measured in 21 Gambian children with severe falciparum malaria after intramuscular administration of a 20 mg (salt) per kg loading dose of quinine dihydrochloride followed by 10 mg/kg at 12 h intervals. Quinine was well absorbed reaching mean peak concentrations of 15·6 (standard deviation [SD] 4·5) mg/litre in a median time of 3 h (range 1-6 h). A one compartment model was fitted to the plasma concentration-time profile. The mean estimated systemic clearance (C1/F) was 0·89 (SD 0·81) ml/kg/min and the mean elimination half life was 18·8 (SD 8·0) h. Two patients, one of whom died, had low plasma quinine levels which remained below 10 mg/litre. Mean peak and trough plasma concentrations after subsequent intramuscular doses ranged between 11·1 and 15·1 mg/litre. In most cases this dose regimen provided a satisfactory profile of blood concentrations for the treatment of severe malaria in children. © 1990, Roy al Society of Tropical Medicine and Hygiene. All rights reserved.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1016/0035-9203(90)90009-4