Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand

Noppawan TunsirimasPornjira PariwatcharakulSomrak ChoovanichvongWoraphat Ratta-aphaSrithanya HospitalFaculty of Medicine, Siriraj Hospital, Mahidol UniversityNakorn Ratchasima Rajanagarindra Psychiatric Hospital2020-01-272020-01-272019-03-01Asian Journal of Psychiatry. Vol.41, (2019), 13-1618762026187620182-s2.0-85062495210https://repository.li.mahidol.ac.th/handle/20.500.14594/51830© 2019 Elsevier B.V. The present study aimed to investigate the incidence of agranulocytosis and leukopenia and its associated factors in Thai schizophrenia patients treated with clozapine and the rate of hematologic adverse events monitored in clinical practice. Data were collected from the medical records of 641 outpatients at two hospitals. The results showed no cases of agranulocytosis and 20 cases of leukopenia (3.1%), 85% of which were observed after 1 year of prescription. The associated factors were female (p = 0.019) and duration of clozapine prescription (p = 0.026). According to the guideline for safety monitoring, 23.6% of cases had neutrophils count monitoring.Mahidol UniversityMedicineClozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in ThailandArticleSCOPUS10.1016/j.ajp.2019.03.002