Chaisrisawadisuk S.Sathienkijkanchai A.Khampalikit I.Moore M.H.Mahidol University2026-04-292026-04-292026-01-21Journal of Craniofacial Surgery Vol.Publish Ahead of Print (2026)10492275https://repository.li.mahidol.ac.th/handle/123456789/116388Multisutural craniosynostosis, involving premature fusion of cranial sutures, leads to abnormal skull shape and elevated intracranial pressure (ICP), threatening neurodevelopment. This case report describes a 6-day-old infant with multisutural craniosynostosis associated with an ERF gene mutation. Imaging confirmed elevated ICP. At 2 months, posterior cranial and foramen magnum decompression effectively reduced ICP, deferring fronto-orbital advancement. By age 2, the child had achieved normal developmental milestones with stable cranial morphology and no Chiari I malformation. Early posterior decompression is a viable first-line intervention for syndromic craniosynostosis, promoting natural bone reformation and reducing secondary surgeries. Multidisciplinary management is essential.MedicineArticleSCOPUS10.1097/SCS.00000000000124572-s2.0-10503584459415363732