Plant Antitumor Agents. 31. The Calycopterones, a New Class of Biflavonoids with Novel Cytotoxicity in a Diverse Panel of Human Tumor Cell Lines

Monroe E. WallMansukh C. WaniFekadu FullasJohn B. OswaldDan M. BrownThawatchai SantisukVichai ReutrakulAndrew T. McPhailNorman R. FarnsworthJohn M. PezzutoA. Douglas KinghornJeffrey M. BestermanRTI InternationalUniversity of Illinois at ChicagoThe Forest Herbarium, Thailand Ministry of Natural Resources and EnvironmentMahidol UniversityP.M. Gross Chemical LaboratoryGlaxoSmithKline, USARoyal Forest HerbariumDuke University2018-02-272018-02-271994-05-01Journal of Medicinal Chemistry. Vol.37, No.10 (1994), 1465-147015204804002226232-s2.0-0028318867https://repository.li.mahidol.ac.th/handle/20.500.14594/9513Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4′,5-dihydroxy-3,3′,6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (Combretaceae). Compounds 1–3 showed a wide range of activity against a panel of solid tumor cell lines. Among the biflavonoids, calycopterone (1) is the major constituent. © 1994, American Chemical Society. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and PharmaceuticsPlant Antitumor Agents. 31. The Calycopterones, a New Class of Biflavonoids with Novel Cytotoxicity in a Diverse Panel of Human Tumor Cell LinesArticleSCOPUS10.1021/jm00036a012