Pintip RuenwongsaSupakorn PattanavibagMahidol University2018-10-122018-10-121984-01-23Life Sciences. Vol.34, No.4 (1984), 365-370002432052-s2.0-0021350958https://repository.li.mahidol.ac.th/handle/20.500.14594/30709The synthesis of whole brain acetylcholine is reduced in thiamine deficient rats produced by prolonged administration of tea. In those rats fed a normal diet and given tea (1:50, w/v) instead of drinking water for 20 weeks, the conversion of [14C] pyruvate to [14C] acetylcholine decreased by 35%. However, no neurological symptoms were observed. Administration of tea to rats fed a thiamine half-deficient diet for 7-8 weeks caused not only 60% decrease in acetylcholine synthesis but also neurological symptoms. This decreased synthesis of acetylcholine is related to a decline in pyruvate dehydrogenase activity. The results suggest that prolonged administration of tea to rats cause an impairment of acetyl CoA production resulting in a deficit in acetylcholine synthesizing capacity. © 1984.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/0024-3205(84)90625-8