Phechkrajang C.Khongkaew P.Limwikrant W.Jaturanpinyo M.Mahidol University2023-06-182023-06-182022-08-01Molecules Vol.27 No.12 (2022)https://repository.li.mahidol.ac.th/handle/20.500.14594/83662Non-destructive analysis of chlorpheniramine maleate (CPM), pharmaceutical tablets, and granules was conducted by chemometrics-assisted attenuated total reflectance infrared spectroscopy (ATR-IR). For tablets, an optimum PLSR model with eight latent factors was obtained from area-normalized and standard normal variate (SNV) pretreated ATR-IR spectral data with correlation coefficients (R2) of calibration and cross-validation of 0.9716 and 0.9602, respectively. The model capability for the 42 test set samples was proven with R2 between the reference and model prediction values of 0.9632, and a root-mean-square error of prediction (RMSEP) of 1.7786. The successive PLSR model for granules was constructed from SNV and first derivative pretreated ATR-IR spectral data with two latent factors and correlation coefficients (R2) of calibration and cross-validation of 0.9577 and 0.9450, respectively.Biochemistry, Genetics and Molecular BiologyArticleSCOPUS10.3390/molecules271237602-s2.0-851328609791420304935744885