Sorot WutthiphanYongyudh VajaradulRungroj LerdvitayasakulTaweekit NimvorapunWanchai KoochingchaiPriest HospitalMahidol UniversityFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityRutnin Eye Hospital2018-07-242018-07-242002-01-01Cell and Tissue Banking. Vol.3, No.2 (2002), 121-126138993332-s2.0-0242584851https://repository.li.mahidol.ac.th/handle/123456789/20108Management of difficult strabismus, such as strabismus fixus and paralytic strabismus, in order to maintain the alignment is complicated. There are many surgical approaches described in the current literature, together with notes on the materials used to stabilize these deformities. We present a new surgical approach using quadriceps tendon allograft for the correction of difficult strabismus such as strabismus fixus and paralytic strabismus. Our idea for using deep frozen quadriceps tendons developed from the fact that this is the most stable and strongest tendon in the whole body. Six patients with strabismus fixus (n = 1), paralytic strabismus secondary to extraocular muscle damage (n = 1) and combined cranial nerve palsy (n = 4) were operated on using a strip of deep frozen quadriceps tendon allograft sutured onto both the globe and the periosteum. The mean age of the patients was 44.33 years. (range 17-71 years) All the patients were followed up for six months. The mean preoperative deviation in the six cases was 60 prism diopters (PD) (range 30-123 PD) The mean change in horizontal alignment at 1 month, 3 months and 6 months postoperatively was 54 PD, 53 PD and 49.16 PD respectively. We had only one case of undercorrection. This may possible be due to the remaining function of the antagonist and/or the fact that we had used the distal end of the quadriceps tendon. When the patient (patient No. 5) who had 2 operations was excluded, the mean change in horizontal alignment was 48.6 PD, 47.4 PD and 43.6 PD. Post-operatively there was no infection or any other complications. According to our study of existing literature, these cases of deep frozen quadriceps tendon allograft application for the indications mentioned above are the first reported cases of its type. We conclude that ocular fixation with quadriceps tendon to the periosteum is a safe and effective option for the management of difficult strabismus. Further research on a larger cohort of patients and longer follow-up time are needed.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyEngineeringMaterials ScienceMedicineArticleSCOPUS10.1023/A:1022872113813