Tanawan KummaluePornchai O-charoenratWeena JiratchariyakulMonraudee ChanchaiKovit PattanapanyasatKasama SukapiromSurat IemsriFaculty of Medicine, Siriraj Hospital, Mahidol UniversityMahidol University2018-08-242018-08-242007-04-04Journal of Ethnopharmacology. Vol.110, No.3 (2007), 439-443037887412-s2.0-33847736210https://repository.li.mahidol.ac.th/handle/20.500.14594/25107Erycibe elliptilimba Merr. & Chun., family Convolvulaceae, is a Thai traditional medicine which has long been prescribed for various infectious and malignant diseases. Bio-assays of extracts from Erycibe elliptilimba Merr. & Chun. showed that a fraction (fraction 3) from an methanolic extract had an antiproliferative effect on SKBR3 and MDA-MB435 human breast cancer cells. The ED50 value of Erycibe elliptilimba Merr. & Chun. fraction 3 was 56.07 and 30.61 μg/ml for SKBR3 and MDA-MB435, respectively. After 48 h of exposure, this fraction at a concentration of 100 μg/ml significantly reduced cell proliferation in both cancer cells. In MDA-MB435 cells, cell cycle analysis showed that the herb extract fraction 3 induced the accumulation of cells in G2/M phase, whereas no significant change in cell cycle was detected in SKBR3 cells. The results indicated that the extract fraction 3 could induce cell cycle arrest in some way. However, further investigation is needed to assess the molecular mechanisms mediated anticancer activities of this plant. © 2006 Elsevier Ireland Ltd. All rights reserved.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.jep.2006.10.025