Amod SharmaMahidol UniversityKhon Kaen University2018-11-232018-11-232015-10-22Journal of Biomedical Science. Vol.22, No.1 (2015)14230127102177702-s2.0-84944711220https://repository.li.mahidol.ac.th/handle/20.500.14594/35361© 2015 Sharma. Animal studies suggest that chronic monosodium glutamate (MSG) intake induces kidney damage by oxidative stress. However, the underlying mechanisms are still unclear, despite the growing evidence and consensus that α-ketoglutarate dehydrogenase, glutamate receptors and cystine-glutamate antiporter play an important role in up-regulation of oxidative stress in MSG-induced renal toxicity. This review summaries evidence from studies into MSG-induced renal oxidative damage, possible mechanisms and their importance from a toxicological viewpoint.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineReviewSCOPUS10.1186/s12929-015-0192-5