Arunporn ItharatAnuchit PlubrukarnPalangpon KongsaereeTam BuiNiwat KeawpradubPeter J. HoughtonKing's College LondonPrince of Songkla UniversityMahidol University2018-07-242018-07-242003-08-07Organic Letters. Vol.5, No.16 (2003), 2879-2882152370602-s2.0-0141631703https://repository.li.mahidol.ac.th/handle/20.500.14594/20702(Matrix presented) Commonly used among ingredients in Thai traditional anticancer preparations, the rhizome of Dioscorea membranacea Pierre was found potently cytotoxic and possibly contributed to such a therapeutic effect. Bioassay-guided isolation resulted in two novel cytotoxic naphthofuranoxepins, dioscorealides A (1) and B (2), and a new 1,4-phenanthraquinone, dioscoreanone (3). The structure determination, achieved mainly by means of NMR and CD spectral and X-ray crystallographic analyses, and cytotoxicity are discussed here.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1021/ol034926y