Bonnie N. JoeVictoria Y. ChenNouha SalibiPornpim FuangtharntipCharles F. HildeboltKyongtae T. BaeUniversity of California, San FranciscoSiemens USAMahidol UniversityWashington University School of Medicine in St. Louis, Mallinckrodt Institute of Radiology2018-06-212018-06-212005-07-01Investigative Radiology. Vol.40, No.7 (2005), 405-411002099962-s2.0-20844433248https://repository.li.mahidol.ac.th/handle/20.500.14594/16947Objectives: We sought to evaluate spectroscopic measurements in breast cancer and compare variability in choline peak parameters related to contrast administration versus that inherent to repeated measurements. Materials and Methods: Single-voxel, proton spectroscopy measurements were obtained before and after the administration of gadolinium on 15 patients with ≥1-cm breast cancers. The protocol was repeated on a separate day in 7 patients. Results: Postcontrast spectra demonstrated a significant increase in choline peak linewidth (day 1: 15% ± 21%, P = 0.03; day 2: 19% ± 12%, P = 0.001) and decrease in choline peak area (day 1: 11% ± 9% (P < 0.001); day 2: 18% ± 21% (P = 0.03). A variance-components analysis indicated that day-to-day variation in linewidth accounted for 0.0% of the total variation in width measurements and was not significant (P = 0.85). Day-to-day variation in area was also not significant (0.0%, P = 0.95). Conclusions: Contrast administration caused significant increases in choline peak linewidth and decreases in choline peak area in spectroscopic measurements of breast cancer. Copyright © 2005 by Lippincott Williams & Wilkins.Mahidol UniversityMedicineArticleSCOPUS10.1097/01.rli.0000167125.79212.5d