Varaporn Buraphacheep JunyaprasertNoppamas SoonthornchareonnonSuchitra ThongpraditchoteTeruo MurakamiMikihisa TakanoMahidol UniversityHiroshima University2018-08-202018-08-202006-01-01Phytotherapy Research. Vol.20, No.1 (2006), 79-81109915730951418X2-s2.0-31644449339https://repository.li.mahidol.ac.th/handle/20.500.14594/23185Curcuminoids from Curcuma longa L. and extracts of Psidium guajava L., Andrographis paniculata (Burm. f.) Nees, Phyllanthus emblica L. and Solanum trilobatum L. were investigated for their inhibitory effect on P-glycoprotein (P-gp) on the efflux transport of rhodamine 123 (Rho-123) in Caco-2 cells and rat ileum. Of the five tested samples, curcuminoids and an extract of P. guajava showed the highest inhibitory effect on P-gp mediated efflux of Rho-123 in Caco-2 cells. Additionally, they were found to have equal potential in inhibiting Rho-123 efflux transport from serosal to mucosal surfaces of the rat ileum. Copyright © 2006 John Wiley & Sons, Ltd.Mahidol UniversityChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1002/ptr.1785