Praphatsorn SaetangVatcharin RukachaisirikulSouwalak PhongpaichitSita PreedanonJariya SakayarojSuparerk BorwornpinyoSawinee SeemakhanChatchai MuanprasatPrince of Songkla UniversityThailand National Center for Genetic Engineering and BiotechnologyMahidol University2018-12-212019-03-142018-12-212019-03-142017-11-01Phytochemistry. Vol.143, (2017), 115-123003194222-s2.0-85026908528https://repository.li.mahidol.ac.th/handle/20.500.14594/41309© 2017 Elsevier Ltd Nine previously undescribed depsidones (simplicildones A-I) and one previously undescribed α-pyrone (simplicilopyrone) were isolated from the endophytic fungus Simplicillium sp. PSU-H41 along with 11 known compounds. Their structures were established by extensive spectroscopic analysis. Simplicildone A and known botryorhodine C displayed weak antibacterial against Staphylococcus aureus with equal MIC values of 32 μg/mL. Additionally, botryorhodine C was active against methicillin-resistant S. aureus with the same MIC value. Simplicildone C exhibited weak antifungal activity against Cryptococcus neoformans with an MIC value of 32 μg/mL. In addition, simplicildones A and C and botryorhodine C were noncytotoxic against noncancerous Vero cells.Mahidol UniversityAgricultural and Biological SciencesBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1016/j.phytochem.2017.08.002