Akiva FeintuchPermyos RuengsakulrachAmy LinJi ZhangYu Qing ZhouJonathon BishopLorinda DavidsonDavid CourtmanF. Stuart FosterDavid A. SteinmanR. Mark HenkelmanC. Ross EthierHospital for Sick Children University of TorontoUniversity of TorontoMahidol UniversitySaint Michael's Hospital University of TorontoSunnybrook Health Sciences Centre2018-08-242018-08-242007-02-01American Journal of Physiology - Heart and Circulatory Physiology. Vol.292, No.2 (2007)15221539036361352-s2.0-33846944350https://repository.li.mahidol.ac.th/handle/20.500.14594/24255Mice are widely used to study arterial disease in humans, and the pathogenesis of arterial diseases is known to be strongly influenced by hemodynamic factors. It is, therefore, of interest to characterize the hemodynamic environment in the mouse arterial tree. Previous measurements have suggested that many relevant hemodynamic variables are similar between the mouse and the human. Here we use a combination of Doppler ultrasound and MRI measurements, coupled with numerical modeling techniques, to characterize the hemodynamic environment in the mouse aortic arch at high spatial resolution. We find that the hemodynamically induced stresses on arterial endothelial cells are much larger in magnitude and more spatially uniform in the mouse than in the human, an effect that can be explained by fluid mechanical scaling principles. This surprising finding seems to be at variance with currently accepted models of the role of hemodynamics in atherogenesis and the known distribution of atheromatous lesions in mice. Copyright © 2007 the American Physiological Society.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1152/ajpheart.00796.2006