Total synthesis of racemosol and de-O-methylracemosol, potent cyclooxygenase (COX) inhibitors and antimalarial agents

Patcharaporn Sae-LaoPrasat KittakoopShuleewan RajviroongitMahidol UniversityThailand National Center for Genetic Engineering and Biotechnology2018-08-202018-08-202006-01-16Tetrahedron Letters. Vol.47, No.3 (2006), 345-348004040392-s2.0-28844486620https://repository.li.mahidol.ac.th/handle/20.500.14594/23097The total synthesis of antimalarial and cyclooxygenase inhibitors, racemosol and de-O-methylracemosol, is described. The key steps involved the lateral lithiation reaction of ortho-methyl tolulate and the pyran formation via a tandem demethylation-cyclization reaction. © 2005 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsTotal synthesis of racemosol and de-O-methylracemosol, potent cyclooxygenase (COX) inhibitors and antimalarial agentsArticleSCOPUS10.1016/j.tetlet.2005.11.016