Patoomratana TuchindaAnawat KumkaoManat PohmakotrSamaisukh SophasanThawatchai SantisukVichai ReutrakulMahidol UniversityThailand Royal Forest Department2018-08-202018-08-202006-01-01Planta Medica. Vol.72, No.1 (2006), 60-62003209432-s2.0-32644435414https://repository.li.mahidol.ac.th/handle/20.500.14594/23113The arylnaphthalide lignan glycosides, taxodiifoloside (1), cleistanthoside A (2), cleistanthin A (3) and cleistanthin A methyl ether (4), together with a triterpene, glochidone (5), have been isolated from the aerial parts of Phyllanthus taxodiifolius. The structures were established using spectral and chemical methods. Compounds 3 and 4, as well as the derivatives 2a and 3a exhibited potent cytotoxic activities with GI50values in the range of 10-7-10-9M in five cultured mammalian cancer cell lines while the new compound 1 showed moderate activity (GI50in the order of 10-6M). Compounds 2 and 5 were inactive in all tested cell lines. © Georg Thieme Verlag KG Stuttgart.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1055/s-2005-873141