Janice Natasha C. NgRungsima WanitphakdeedechaChadakan YanFaculty of Medicine, Siriraj Hospital, Mahidol University2020-08-252020-08-252020-01-01Journal of Cosmetic Dermatology. (2020)14732165147321302-s2.0-85088564325https://repository.li.mahidol.ac.th/handle/20.500.14594/58234© 2020 Wiley Periodicals LLC Background: The use of light-emitting diode (LED) in combination wavelength for facial rejuvenation has been previously reported. Nowadays, there has been a growing market for home-use cosmetic devices because of its low cost and convenience. Aims: To evaluate the efficacy and safety of home-use LED device on facial rejuvenation. Methods: This was a prospective split-face clinical trial with a total of 24 subjects, who presented with photo aging skin. All subjects were treated with the home-use LED device on the left side of their face, twice a week for 8 weeks. Primary outcomes measured in the study were the changes in the biophysical properties of the skin assessed with the following parameters: skin elasticity, skin hydration, texture, and wrinkles. Evaluations were done at baseline, 2-, 4-, 6-, and 8-week follow-up. Subjects’ self-improvement scores and adverse reactions were also recorded. Results: All 24 subjects completed the study and attended all follow-up. Skin elasticity was significantly higher in the LED group compared to the control during the 6- and 8-week follow-up (P <.05). In the LED group, an image of the treated skin captured using Visioscan® showed improvement of the skin texture at 8-week follow-up. Majority of the subjects in the LED group scored good improvement on all follow-ups (37.5%, 41.7%, 58.3%, and 62.5%) when compared to the baseline. No adverse reactions or pain were recorded in the study. Conclusion: The home-use LED device, with a combination wavelength of 637 and 854 nm, is safe and can be used as an adjunctive treatment for self-administered facial rejuvenation.Mahidol UniversityMedicineArticleSCOPUS10.1111/jocd.13613