Arada Rojana-UdomsartChalermchai MitrpantIan JamesCampbell WittMerrilee NeedhamTimothy DayLynette KiersAlastair CorbettPatricia MartinezSteve D. WiltonFrank L. MastagliaUniversity of Western AustraliaYala HospitalMahidol UniversityRoyal Perth HospitalRoyal North Shore HospitalUniversity of Sydney Faculty of MedicineRoyal Melbourne HospitalUniversity of MelbourneConcord Repatriation General Hospital2018-10-192018-10-192013-01-15Journal of Neuroimmunology. Vol.254, No.1-2 (2013), 174-17718728421016557282-s2.0-84871690509https://repository.li.mahidol.ac.th/handle/20.500.14594/31975We compared the carriage frequencies of HLA-DRB3 and its major alleles and of HLA-DRB4 and HLA-DRB5 in an Australian sIBM cohort and a population control group who had previously been genotyped for the HLA-DRB1*03:01 risk allele. There was a strong disease association with the carriage of the DRB3*01:01 allele which was accounted for by its linkage disequilibrium with DRB1*03:01. The carriage of HLA-DRB4 was found to be strongly protective and abrogated the risk effect of HLA-DRB1*03:01. The findings indicate that haplotypic combinations of alleles at the HLA-DRB1 and secondary HLA-DRB loci have important risk modifying effects in sIBM. © 2012 Elsevier B.V.Mahidol UniversityImmunology and MicrobiologyMedicineNeuroscienceArticleSCOPUS10.1016/j.jneuroim.2012.09.003