Joan E. HilnerLetitia H. PerdueElizabeth G. SidesJune J. PierceAna M. WägnerAlan AldrichAmanda LothLotte AlbretLynne E. WagenknechtConcepcion NierrasBeena AkolkarTracey BaskervilleNines BautistaEesh BhatiaVijayalakshmi BhatiaKamaruzaman Bin HasanFrancois BonniciThomas BrodnickiBrian BrowningFergus CameronKatharee ChaichanwatanakulPik To CheungPeter ColmanAndrew CotterillJenny CouperPatricia CrockRic CutfieldTim DavisPaul DixonKim DonaghueKatrina DowlingPaul DrurySarah DyeShane GellertRohana Abdul GhaniRistan GreerXueyao HanLen HarrisonNick HomatopoulosLinong JiTim JonesLoke Kah YinNor Azmi KamaruddinUma KangaAlok KanungoGurvinder KaurBetty KekSimon KnowlesJeremy KrebsNeeraj KumarYann Jinn LeeXiaoying LiSupawadee LiktimaskulMargaret LloydAmanda LothAnthony LoueyNarinder MehraTony MerrimanLiu MinGrant MorahanRobert MosesGrant MrazRinki MurphyIan NicholsonAraceli PaneloPerlita PohGareth PriceNirubasini RatnamCarani SanjeeviSaikiran SedimbiShuixian ShenGoh Siok YingBrian TaitNikhil TandonAllison ThomasMike VarneyPraewvarin WeerakulwattanaJinny WillisElvis Abang AkwoLotte AlbretFrancisco Ampudia-BlascoJesus ArgenteMagdalena AvbeljGulja BabadjanovaKlaus BadenhoopTadej BattelinoGeorg BeilhackRegine BergholdtPolly BingleyBernhard BoehmJo BolidsonKerstin BrismarCaroline BrorssonJoyce CarlsonLuis CastanoKyla ChandlerValentino CherubiniOndrej CinekUniversity of Alabama at BirminghamWake Forest University Health SciencesHagedorn Research InstituteHospital Insular, Las PalmasUniversidad de Las Palmas de Gran CanariaUniversity of Alaska AnchorageWalter and Eliza Hall Institute of Medical ResearchJuvenile Diabetes Research Foundation InternationalNational Institute of Diabetes and Digestive and Kidney DiseasesMater HospitalInstitute for Study on Diabetes FoundationSanjay Gandhi Postgraduate Institute of Medical Sciences LucknowNational University of Malaysia HospitalUniversity of Cape TownUniversity of AucklandRoyal Children's Hospital, MelbourneMahidol UniversityQueen Mary Hospital Hong KongWomen’s and Children’s HospitalJohn Hunter Children’s HospitalNorth Shore HospitalFremantle Hospital and Health ServiceDiabetes Lifestyle CentreChildren's Hospital At WestmeadAustralian Red Cross Blood ServiceAuckland Diabetes CentreWestern Australia Institute for Medical ResearchRoyal Melbourne HospitalUniversity of QueenslandPeking UniversityPrincess Margaret Hospital for ChildrenChildren's Medical InstituteAll India Institute of Medical Sciences, New DelhiCuttack Diabetes Research FoundationDiabetes CentreMackay Memorial Hospital TaiwanShanghai Jiao Tong UniversityUniversity of OtagoBeijing Children's HospitalIllawarra Diabetes ServicesInstitute for Studies on Diabetes FoundationMater Medical Research InstituteKarolinska University HospitalFudan UniversityChristchurch Hospital New ZealandCentral Hospital of Yaounde FMBSSteno Diabetes CenterClinic University Hospital ValenciaHospital Infantil Universitario Niño JesúsUniversity Children’s HospitalSechenov First Moscow State Medical UniversityKlinikum und Fachbereich Medizin Johann Wolfgang Goethe-Universitat Frankfurt am MainUniversitat UlmUniversity of BristolMalmo University HospitalHospital de CrucesSalesi HospitalFakultni Nemocnice v MotoleUniversity Campus Bio-Medico2018-09-242018-09-242010-08-01Clinical Trials. Vol.7, No.1_suppl (2010), S5-S3217407753174077452-s2.0-79952279467https://repository.li.mahidol.ac.th/handle/20.500.14594/29920© The Author(s) 2010. Background and Purpose The Type 1 Diabetes Genetics Consortium (T1DGC) is an international project whose primary aims are to: (a) discover genes that modify type 1 diabetes risk; and (b) expand upon the existing genetic resources for type 1 diabetes research. The initial goal was to collect 2500 affected sibling pair (ASP) families worldwide. Methods T1DGC was organized into four regional networks (Asia-Pacific, Europe, North America, and the United Kingdom) and a Coordinating Center. A Steering Committee, with representatives from each network, the Coordinating Center, and the funding organizations, was responsible for T1DGC operations. The Coordinating Center, with regional network representatives, developed study documents and data systems. Each network established laboratories for: DNA extraction and cell line production; human leukocyte antigen genotyping; and autoantibody measurement. Samples were tracked from the point of collection, processed at network laboratories and stored for deposit at National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) Central Repositories. Phenotypic data were collected and entered into the study database maintained by the Coordinating Center. Results T1DGC achieved its original ASP recruitment goal. In response to research design changes, the T1DGC infrastructure also recruited trios, cases, and controls. Results of genetic analyses have identified many novel regions that affect susceptibility to type 1 diabetes. T1DGC created a resource of data and samples that is accessible to the research community. Limitations Participation in T1DGC was declined by some countries due to study requirements for the processing of samples at network laboratories and/or final deposition of samples in NIDDK Central Repositories. Re-contact of participants was not included in informed consent templates, preventing collection of additional samples for functional studies. Conclusions T1DGC implemented a distributed, regional network structure to reach ASP recruitment targets. The infrastructure proved robust and flexible enough to accommodate additional recruitment. T1DGC has established significant resources that provide a basis for future discovery in the study of type 1 diabetes genetics.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1177/1740774510373497