Annelies Wilder-SmithPeter ByassPhanthip OlanratmaneePongsri MaskhaoLuechai SringernyuangJames G. LoganSteve W. LindsaySarah BanksDuane GublerValérie R. LouisYesim TozanPattamaporn KittayapongUmea UniversitetUniversitat HeidelbergMahidol UniversityRajabhat Rajanagarindra UniversityLondon School of Hygiene & Tropical MedicineProgram in Emerging Infectious DiseasesBoston University School of Public Health2018-06-112018-06-112012-11-15Trials. Vol.13, (2012)174562152-s2.0-84868702384https://repository.li.mahidol.ac.th/handle/20.500.14594/14522Background: There is an urgent need to protect children against dengue since this age group is particularly sensitive to the disease. Since dengue vectors are active mainly during the day, a potential target for control should be schools where children spend a considerable amount of their day. School uniforms are the cultural norm in most developing countries, worn throughout the day. We hypothesise that insecticide-treated school uniforms will reduce the incidence of dengue infection in school-aged children. Our objective is to determine the impact of impregnated school uniforms on dengue incidence.Methods: A randomised controlled trial will be conducted in eastern Thailand in a group of schools with approximately 2,000 students aged 7-18 years. Pre-fabricated school uniforms will be commercially treated to ensure consistent, high-quality insecticide impregnation with permethrin. A double-blind, randomised, crossover trial at the school level will cover two dengue transmission seasons.Discussion: Practical issues and plans concerning intervention implementation, evaluation, analysing and interpreting the data, and possible policy implications arising from the trial are discussed.Trial registration: clinicaltrial.gov. Registration number: NCT01563640. © 2012 Wilder-Smith et al.; licensee BioMed Central Ltd.Mahidol UniversityMedicineArticleSCOPUS10.1186/1745-6215-13-212