Suphakarn TechapongsatornAmarit TansawetWisit KasetsermwiriyaMark McEvoyJohn AttiaChumpon WilasrusmeeAmmarin ThakkinstianVajira HospitalUniversity of Newcastle, Faculty of Health and MedicineFaculty of Medicine, Ramathibodi Hospital, Mahidol University2020-01-272020-01-272019-08-01Surgeon. Vol.17, No.4 (2019), 215-2241479666X2-s2.0-85055428723https://repository.li.mahidol.ac.th/handle/20.500.14594/51514© 2018 The Authors Laparoscopic totally extra-peritoneal inguinal hernia repair is the standard option for inguinal hernia treatment. However, there are various types of mesh fixation and their relative uses are still controversial. This network meta-analysis was conducted to compare and rank the different fixations available for TEP. Medline and Scopus databases were search until February 1, 2017 and using randomized controlled trials comparing outcomes between different mesh fixation techniques were included. The results demonstrated that fifteen RCTs (n = 1783) were eligible for pooling. Five types of mesh fixation were used; metallic tack, no-fixation, absorbable tack, suture, and glue. Network meta-analysis that use metallic tack as the reference, indicated that suture and glue both carried a lower risk of recurrence with pooled risk ratios (RR) of 0.29 (95% CI 0.00, 18.81) and 0.29 (0.07, 1.30), respectively. For overall complications, absorbable tack had lower risk (0.63, 95% CI: 0.02, 16.13). However, none of these estimates reached statistical significance. So, this network meta-analysis suggests that glue and absorbable tack might be best in lowering recurrence risk and complications. However, a large scale RCT is still needed to confirm these results.Mahidol UniversityMedicineArticleSCOPUS10.1016/j.surge.2018.09.002