Farkhan A.Lawpoolsri S.Soonthornworasiri N.Pakasi T.T.Sulistyo S.Salsabila A.Maude R.J.Surendra H.Rotejanaprasert C.Mahidol University2026-02-212026-02-212026-12-01Infectious Diseases of Poverty Vol.15 No.1 (2026)20955162https://repository.li.mahidol.ac.th/handle/123456789/115190Background: Indonesia ranks among the countries with the highest burden of drug-resistant tuberculosis (DR-TB), contributing approximately 7.4% of global cases, many of which are likely underdiagnosed. To support targeted public health surveillance and control efforts, this study aimed to characterize the spatiotemporal distribution of DR-TB incidence in Indonesia, identify geographic hotspots, and examine associations with health system and socioeconomic factors. Methods: We conducted a nationwide retrospective analysis using annual DR-TB notification data from 2017 to 2022 across all 514 districts, obtained from the national tuberculosis information system. Multivariable Bayesian spatiotemporal regression models were fitted under alternative likelihood assumptions and space-time random effect structures. Model selection criteria were used to identify the best-fitting models for hotspot detection and estimation of risk factor associations. Results: DR-TB predominantly affected individuals aged 25–54 years, aligning with the working-age population. Hotspots were concentrated in urbanized regions, including the Jabodetabek megacity, Greater Surabaya, and districts in South Sumatra. The best-fitting model identified a protective association between first-line treatment success rates and DR-TB incidence [incidence rate ratio (IRR): 0.508; 95% credible interval (CrI): 0.368–0.702]. In contrast, DR-TB incidence was positively associated with the proportion of the population living below the poverty line (IRR: 1.028; 95% CrI: 1.013–1.044), households with improved sanitation access (IRR: 1.006; 95% CrI: 1.002–1.010), and increased municipal human development index (IRR: 1.068; 95% CrI: 1.049–1.094). Conclusions: DR-TB hotspots were primarily concentrated in urban areas, highlighting the need for targeted interventions. Improving first-line tuberculosis treatment success rates and addressing socioeconomic drivers, such as poverty, are critical for controlling DR-TB. Public health policies should prioritize workplace-based support for improving treatment adherence, provide safeguards for TB patients affected by poverty, and underscore the importance of a multisectoral TB surveillance and control program.MedicineArticleSCOPUS10.1186/s40249-026-01418-92-s2.0-10502991511820499957