Harald MischakRolf ApweilerRosamonde E. BanksMark ConawayJoshua CoonAnna DominiczakJochen H.H. EhrichDanilo FliserMark GirolamiHenning HermjakobDenis HochstrasserJoachim JankowskiBruce A. JulianWalter KolchZiad A. MassyChristian NeusuessJan NovakKarlheinz PeterKasper RossingJoost SchanstraO. John SemmesDan TheodorescuVisith ThongboonkerdEva M. WeissingerJennifer E. Van EykTadashi YamamotoMosaiques Diagnostics and Therapeutics AGEuropean Bioinformatics InstituteSt James's University HospitalUniversity of VirginiaUniversity of Wisconsin MadisonUniversity of GlasgowMedizinische Hochschule Hannover (MHH)Charité – Universitätsmedizin BerlinUniversite de GeneveUniversity of Alabama at BirminghamBeatson Institute for Cancer ResearchInsermUniversity of AalenBaker Heart and Diabetes InstituteSteno Diabetes CenterEastern Virginia Medical SchoolMahidol UniversityJohns Hopkins UniversityNiigata University School of MedicineCHU Amiens Picardie2018-08-242018-08-242007-02-01Proteomics - Clinical Applications. Vol.1, No.2 (2007), 148-156186283462-s2.0-34047209848https://repository.li.mahidol.ac.th/handle/123456789/24257The aim of this manuscript is to initiate a constructive discussion about the definition of clinical proteomics, study requirements, pitfalls and (potential) use. Furthermore, we hope to stimulate proposals for the optimal use of future opportunities and seek unification of the approaches in clinical proteomic studies. We have outlined our collective views about the basic principles that should be considered in clinical proteomic studies, including sample selection, choice of technology and appropriate quality control, and the need for collaborative interdisciplinary efforts involving clinicians and scientists. Furthermore, we propose guidelines for the critical aspects that should be included in published reports. Our hope is that, as a result of stimulating discussion, a consensus will be reached amongst the scientific community leading to guidelines for the studies, similar to those already published for mass spectrometric sequencing data. We contend that clinical proteomics is not just a collection of studies dealing with analysis of clinical samples. Rather, the essence of clinical proteomics should be to address clinically relevant questions and to improve the state-of-the-art, both in diagnosis and in therapy of diseases. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1002/prca.200600771