Manat PohmakotrKanhokthron BoonkitpattarakulWinai IeawsuwanSuwatchai JarussophonNongnaphat DuangdeePatoomratana TuchindaVichai ReutrakulMahidol UniversityThailand Ministry of Science and Technology2018-08-202018-08-202006-06-19Tetrahedron. Vol.62, No.25 (2006), 5973-5985004040202-s2.0-33646549878https://repository.li.mahidol.ac.th/handle/20.500.14594/23022α,α-Difluoro-α-phenylsulfanyl-α-trimethylsilylmethane (PhSCF2SiMe3) has been demonstrated as an α,α-difluoro-α-phenylsulfanylmethyl carbanion equivalent. gem-Difluorophenylsulfanylmethylation of carbonyl compounds has been successfully achieved by using PhSCF2SiMe3in the presence of TBAF in THF. The adducts have been converted to the corresponding gem-difluoroalkenes by a novel pyrolytic and/or FVP elimination of the β-hydroxy-α-phenylsufinyl derivatives under reduced pressure. © 2006 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.tet.2006.04.015