Jutamas ApisornopasPatamawadee SilalaiTeerapich KasemsukAnan AthipornchaiUthaiwan SirionKanoknetr SuksenPawinee PiyachaturawatApichart SuksamrarnRungnapha SaeengRambhai Barni Rajabhat UniversityRamkhamhaeng UniversityMahidol UniversityBurapha University2019-08-232019-08-232018-05-15Bioorganic and Medicinal Chemistry Letters. Vol.28, No.9 (2018), 1558-1561146434050960894X2-s2.0-85044503580https://repository.li.mahidol.ac.th/handle/20.500.14594/45167© 2018 Elsevier Ltd New iridoid glycoside derivatives from durantoside I, the latter from the dried flowers and leaves of Citharexylum spinosum, were synthesized by variously modifying a sugar moiety by silylation or acetylation and/or removal of cinnamate group at C-7 position and subsequent screening for comparative cytotoxicity against several cancer cell lines. Addition of alkylsilane to durantoside I and removal of cinnamate group were most effective in improving cytotoxicity.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.bmcl.2018.03.068