Thibaut CourantSirirat KumarnLong HePascal RetailleauGéraldine MassonInstitut de Chimie des Substances NaturellesChulabhorn Research InstituteMahidol University2018-10-192018-10-192013-03-25Advanced Synthesis and Catalysis. Vol.355, No.5 (2013), 836-84016154169161541502-s2.0-84875458564https://repository.li.mahidol.ac.th/handle/20.500.14594/31483An enantioselective aza-Friedel-Crafts reaction of indoles with γ-hydroxy-γ-lactams using a chiral phosphoric acid catalyst is reported. The approach described herein provides an efficient access to 5-indolylpyrrolidinones in good to quantitative yields and excellent enantioselectivities (up to >99% ee). The results suggest that the reaction may proceed via N-acyliminium intermediates associated with the chiral phosphoric acid anion. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Mahidol UniversityChemical EngineeringChemistryArticleSCOPUS10.1002/adsc.201201008