Sudaratana Rochanakij KrungkraiYongyuth YuthavongRajavithi HospitalMahidol University2018-06-142018-06-141987-01-01Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.81, No.5 (1987), 710-714003592032-s2.0-0023622465https://repository.li.mahidol.ac.th/handle/20.500.14594/15361The antimalarial activity of qinghaosu (artemisinine) against Plasmodium falciparum in culture was enhanced by increased oxygen tension. Artesunate, a qinghaosu derivative, showed synergistic effects with miconazole, and with doxorubicin, both of which have been suggested to exert their chemotherapeutic effect through increasing the oxidant stress. In contrast, catalase, dithiothreitol and α-tocopherol reduced the effectiveness of qinghaosu in vitro. These results suggest that the action of qinghaosu and artesunate might involve increase in oxidant stress on the infected red cells. © 1987.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1016/0035-9203(87)90003-4