Pornpen SrisawasdiTanida SuwalakChonlaphat SukasemAnchalee ChittammaAnothai PocathikornSomlak VanavananApichaya PuangpetchSiwalee SantonWasun ChantratitaSasisopin KiertiburanakulMartin H. KrollMahidol UniversityFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityPrince of Songkla UniversityQuest Diagnostics2018-10-192018-10-192013-10-01American Journal of Clinical Pathology. Vol.140, No.4 (2013), 506-51519437722000291732-s2.0-84884959749https://repository.li.mahidol.ac.th/handle/20.500.14594/32137Objectives: To examine whether the lipid parameters are predicting factors for human immunodeficiency virus (HIV)- associated lipodystrophy. Methods: Whole-body fat compositions of HIV-positive patients receiving stavudine-containing antiretroviral regimens (n = 79) were determined. Lipodystrophy was defined as a ratio of trunk fat mass/lower limb fat mass greater than 2.28. Blood samples were analyzed for total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), small-dense LDL-C (sdLDL-C), apoAI, apoB, lipoprotein(a), and CD4 cell counts. Large-buoyant LDL-C (lbLDL-C) was calculated (LDL-C minus sdLDL-C). Results: Twenty-six patients were classified as having lipodystrophy. The mean values of triglycerides, HDL-C, sdLDL-C, apoB, TC/HDL-C, apolipoprotein (apo) B/apoAI, and sdLDL-C/lbLDL-C showed significant differences between patients with and without lipodystrophy (P < .02). Using logistic regression analysis, sdLDL-C/lbLDL-C was identified as a significant predictor of lipodystrophy (P < .001). At a ratio of 0.554, the odds ratio was 17.8 with a likelihood ratio of 5.5. Conclusions: The sdLDL-C/lbLDL-C ratio is an excellent marker for indicating lipodystrophy in HIV-infected patients. © American Society for Clinical Pathology.Mahidol UniversityMedicineArticleSCOPUS10.1309/AJCPE5I3KELTBXEJ