Plangsiri S.Ngamdachakij P.Jirapornsuwan M.Thepyasuwan P.Sribangpleenoi C.Kitgrongpaibul P.Thongchai V.Tangmesang S.Mahidol University2025-09-212025-09-212025-09-01Journal of Surgical Case Reports Vol.2025 No.9 (2025)https://repository.li.mahidol.ac.th/handle/123456789/112094Dual primary malignancy is a rare but possible malignancy presentation. Here, we present two cases of synchronous renal cell cancer and colon cancer with simultaneous laparoscopic management. The first patient, a 65-year-old female, reported painless hematochezia, while the second, a 73-year-old female, complained of painful bloating and constipation, along with a palpable mass in the left lower quadrant of the abdomen. A computed tomography (CT) scan of both patients’ abdomens revealed the expected colonic masses. However, surprisingly, the scans also showed hypervascular masses with peripheral enhancement in the kidneys, suggestive of renal cell carcinoma. No evidence of metastasis was found in either patient. A simultaneous laparoscopic sigmoidectomy combined with radical nephrectomy was successfully performed for both patients. Postoperative CT scans and sigmoidoscopy confirmed complete tumor resection with no evidence of local recurrence. The present case report may serve as a valuable reference for managing similar clinical scenarios in the future.MedicineArticleSCOPUS10.1093/jscr/rjaf7222-s2.0-10501544862520428812