Melanie J. HezzellAdrian BoswoodYu Mei ChangWalasinee MoonarmartJonathan ElliottRoyal Veterinary College University of LondonMahidol UniversityLaboratory consumables were provided by CEVA Santé Animale2018-06-112018-06-112012-11-01American Journal of Veterinary Research. Vol.73, No.11 (2012), 1765-1774000296452-s2.0-84868348778https://repository.li.mahidol.ac.th/handle/20.500.14594/15228Objective-To assess relationships among serum N-terminal procollagen type III concentration, urinary aldosterone-to-creatinine concentration ratio (UAC), and clinical variables in dogs with myxomatous mitral valve disease (MMVD) and healthy dogs. Animals-162 dogs with MMVD and 24 healthy control dogs of comparable age and body weight. Procedures-Blood and urine samples were collected from each dog. Dogs with MMVD underwent echocardiography and ECG. Ventricular diameter measurements were normalized for body weight. Serum N-terminal procollagen type III and urinary aldosterone concentrations were measured via radioimmunoassay. Each dog was examined on 1 to 3 occasions. Examinations were repeated at approximately 6-month intervals. Results-Serum N-terminal procollagen type III concentration decreased with increasing severity of MMVD and was negatively associated with age and left ventricular end-diastolic and end-systolic diameters. The UAC increased with prior percentage change in left ventricular end-diastolic diameter per month, subsequent percentage change in left ventricular end-systolic diameter per month, and treatment with diuretics and was negatively associated with age. Both UAC and serum N-terminal procollagen type III concentration were higher in Cavalier King Charles Spaniels than in other breeds when other measured variables were controlled for. Conclusions and Clinical Relevance-In dogs with MMVD, echocardiographic indicators of left ventricular remodeling appeared to be associated with a decrease in serum concentration of a marker of collagen type III turnover and an increase in urinary aldosterone concentration.Mahidol UniversityVeterinaryArticleSCOPUS10.2460/ajvr.73.11.1765