Chan Hee LeeWaraporn SrikhumAndrew J. BurghardtWarapat VirayavanichJohn B. ImbodenThomas M. LinkXiaojuan LiUniversity of California, San FranciscoDongguk University Ilsan HospitalThammasat UniversityMahidol UniversityUniversity of California SystemSan Francisco General Hospital and Trauma Center2018-11-232018-11-232015-07-01International Journal of Rheumatic Diseases. Vol.18, No.6 (2015), 628-6391756185X175618412-s2.0-84940447253https://repository.li.mahidol.ac.th/handle/20.500.14594/36393© 2015 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd. Aim: In rheumatoid arthritis (RA) hands, we applied high-resolution peripheral quantitative computed tomography (HR-pQCT) and 3 Tesla (3 T) magnetic resonance imaging (MRI), which are new methods for erosion detection and bone marrow edema (BME) quantification. We compared the erosion measurements between these techniques with conventional radiographs (CR) in order to examine their significance for evaluating structural abnormalities. Methods: In 16 RA patients, HR-pQCT of metacarpophalangeal and wrist joints, 3 T MRI of wrist joints, as well as CR in both hands and feet were performed. Ten patients had 1-year follow-up CR. CRs were graded according to the modified Sharp score (MSS). Bone erosions were evaluated in HR-pQCT and MRI. BME pattern was quantified from MRI for volume, signal change and total burden. Results: The erosion detection sensitivity of MRI was 85.7% and CR was 60.9% when HR-pQCT was considered as a reference method. The smallest dimensions of erosion detected by HR-pQCT, MRI and CR were 0.09, 0.14 and 0.66 cm, respectively. Baseline total MSS was correlated with HR-pQCT erosion measures, MRI erosion measures and MRI BME volume (P < 0.05). The mean difference between baseline and 1-year follow-up MSS (delta MSS) was 1.2. A trend was observed toward a correlation between delta MSS and MRI BME volume and burden. Conclusion: This study demonstrates that HR-pQCT detects more and smaller bone erosions compared to MRI and CR. In addition, 3 T MRI can provide quantitative measurement of BME. Combination of HR-pQCT and MRI modalities may provide powerful tools to evaluate joint inflammation and bone damage in RA.Mahidol UniversityMedicineArticleSCOPUS10.1111/1756-185X.12495