Cheol In KangJae Hoon SongSo Hyun KimDoo Ryeon ChungKyong Ran PeckVisanu ThamlikitkulHui WangThomas Man Kit SoPo Ren HsuehRohani Md YasinCelia C. CarlosPham Hung VanJennifer PereraSungKyunKwan University, School of MedicineAsia Pacific Foundation for Infectious Diseases (APFID)Mahidol UniversityPeking Union Medical CollegePrincess Margaret Hospital Hong KongNational Taiwan University HospitalInstitute for Medical Research Kuala LumpurGokilaUniversity of Medicine and PharmacyUniversity of ColomboPeking UniversitySureCare Medical Centre2018-10-192018-10-192013-01-01Journal of Infection. Vol.66, No.1 (2013), 34-4015322742016344532-s2.0-84870729932https://repository.li.mahidol.ac.th/handle/123456789/32701Objective: This study was performed to identify risk factors for the development of bacteremic pneumonia and to evaluate the impact of bacteremia on the outcome of pneumococcal pneumonia. Methods: Using a database from a surveillance study of community-acquired pneumococcal pneumonia, we compared data of the bacteremic group with that of the non-bacteremic group. Results: Among 981 adult patients with pneumococcal pneumonia, 114 (11.6%) patients who had documented pneumococcal bacteremia were classified into the bacteremic group. In a multivariable analysis, use of immunosuppressant drugs, younger age (<65 years), and DM were independent risk factors associated with the development of bacteremic pneumonia among patients with pneumococcal pneumonia (all P < 0.05). The mortality rate was significantly higher in the bacteremic group than in the non-bacteremic group (28.6% vs. 8.5%; P < 0.001). The multivariable analysis revealed that concomitant bacteremia was one of the significant risk factors associated with mortality (OR, 2.57; 95% CI, 1.24-5.29), along with cerebrovascular disease and presentation with septic shock (all P < 0.05). Conclusions: Bacteremia was a common finding in pneumococcal pneumonia and was associated with a higher mortality rate. Several clinical variables may be useful for predicting bacteremic pneumonia among patients with pneumococcal pneumonia. © 2012.Mahidol UniversityMedicineArticleSCOPUS10.1016/j.jinf.2012.08.011